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Table 4: 
MRI white matter signal abnormality (all sizes) characteristics of non-familial healthy control subjects and the healthy relatives of patients with multiple sclerosis
Non-Familial HCs (n = 82)Healthy Relatives of Patients with MS (n = 68)P Value
Subjects with WM SAs, n (%)29 (35.4)28 (41.2).465
    Subjects with WM JC SAs, n (%)4 (4.9)7 (10.3).205
    Subjects with WM PVL SAs, n (%)7 (8.5)14 (20.6).034
    Subjects with WM IT SAs, n (%)1 (1.2)1 (1.5) 0.894
    Subjects with DWM SAs, n (%)28 (34.1)26 (38.2).603
Subjects with ≥9 WM SAs, n (%)5 (6.1)8 (11.8).219
WM-SAN, mean (SD) median2.5 (7.5) 03.8 (10) 0.386
    WM JC SAN, mean (SD) median0.07 (0.3) 00.19 (0.7) 0.207
    WM PVL SAN, mean (SD) median0.41 (2.1) 00.57 (1.9) 0.043
    WM IT SAN, mean (SD) median0.01 (0.1) 00.01 (0.12) 0.894
    WM DWM SAN, mean (SD) median1.9 (5.3) 03.1 (8.5) 0.468
WM-SAV, mean (SD) median198.2 (1085.2)259.7 (784.4).338
DAWM-SAV,a mean (SD) median675.3 (554.7)866.2 (669.3).054
WM-SAV + DAWM-SAV, mean (SD) median873.5 (1233.5)1125.9 (1076.8).025
  • Note:—SAs indicates signal abnormalities; SAN, signal abnormality number; JC, juxtacortical; PVL, periventricular; IT, infratentorial; DWM, deep white matter; SAV, signal abnormality volume.
  • Differences between the groups were compared by means of the χ2 test or Mann-Whitney U test.
  • The SAV is expressed in millimeters cubed (mm3).
  • ↵a DAWM calculation was not related to the size of the hyperintensities.