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Table 5: Non-familial healthy control subjects and the healthy relatives of patients with multiple sclerosis fulfilling Okuda criteria for RIS or fulfilling modified Okuda criteria for RIS in which the dissemination in space on MRI was evaluated by use of Swanton criteria (RIS-Swanton)
Non-Familial HCs (n = 82) Healthy Relatives of Patients with MS (n = 68) P Value
RIS-Okuda criteria¹³ 
    Non-RIS 80 66 .849
    RIS 2 2 
        Subject 1 >9 WM SA: 5 JC, 3 PVL, 13 DWM >9 WM SA: 5 JC, 3 PVL, 13 DWM 
        Subject 2 >9 WM SA: 1 JC, 8 PVL, 11 DWM >9 WM SA: 1 JC, 8 PVL, 11 DWM 
    Total 82 68 
Modified Okuda criteria (RIS-Swanton^13,17) 
    Non-RIS 79 61 .105
    RIS 3 7 
        Subject 1 >9 WM SA: 2 JC, 5 PVL, 9 DWM >9 WM SA: 5 JC, 3 PVL, 13 DWM 
        Subject 2 >9 WM SA: 1 JC, 15 PVL, 18 DWM >9 WM SA: 1 JC, 8 PVL, 11 DWM 
        Subject 3 >9 WM SA: 1 JC, 1 PVL, 11 DWM >9 WM SA: 2 JC, 1 PVL, 7 DWM 
        Subject 4 >9 WM SA: 1 JC, 1 PVL, 24 DWM 
        Subject 5 >9 WM SA: 1 JC, 1 PVL, 7 DWM 
        Subject 6 >9 WM SA: 1 JC, 1 PVL, 8 DWM 
        Subject 7 2 JC, 2 PVL 3 DWM 
    Total 82 68 
Note:—SA indicates signal abnormality; JC, juxtacortical; PVL, periventricular; DWM, deep white matter.
Differences between the groups were compared by means of the χ² test. The regional localization data for subjects fulfilling RIS criteria are presented on individual subject level.