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Array
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Table 5: Base case and scenario analyses
Strategy Cost Incremental Cost ($) Effectiveness (QALYs) Incremental Effectiveness Incremental Cost-Effectiveness ICER
Base case
    CEA $24,624 6.83 3605 
    CAS $30,731 $6107.00 6.71 −0.12 4580 Dominated^a
SAPPHIRE
    CEA $77,377 $14,801.48 5.14 −1.96 15049 Dominated^a
    CAS $62,576 7.1 8814 
EVA-3S
    CEA $22585 6.82 $3312 
    CAS $30,832 $8246.38 6.67 −0.15 $4695 Dominated^a
CREST
    CEA $22,259 6.89 $3227 
    CAS $25,846 $3587.00 6.63 −0.27 $3900 Dominated^a
Note:—ICER indicates incremental cost-effectiveness ratio.
↵a “Dominated” means that the treatment modality was associated with more cost and less effectiveness.

Strategy	Cost	Incremental Cost ($)	Effectiveness (QALYs)	Incremental Effectiveness	Incremental Cost-Effectiveness	ICER
Base case
CEA	$24,624		6.83		3605
CAS	$30,731	$6107.00	6.71	−0.12	4580	Dominated^a
SAPPHIRE
CEA	$77,377	$14,801.48	5.14	−1.96	15049	Dominated^a
CAS	$62,576		7.1		8814
EVA-3S
CEA	$22585		6.82		$3312
CAS	$30,832	$8246.38	6.67	−0.15	$4695	Dominated^a
CREST
CEA	$22,259		6.89		$3227
CAS	$25,846	$3587.00	6.63	−0.27	$3900	Dominated^a