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Table 2: Spatial coordinates, extent, and average CTh of areas showing significant cortical thinning between patients with ALS and HCs
Area Talairach Coordinates (x, y, z) Surface Extension (mm²) ALS Mean CTh (mm) HC Mean CTh (mm)
Right hemisphere, lateral surface (see Fig 1 for reference)
1 0, 97, −35 178 2.778 2.891
2 13, 74, −33 713 2.482 2.687
3 −12, −2, 69 39 2.462 2.793
4 22, 13, 39 15 2.662 2.952
5 23, 27, −69 269 3.152 3.387
Left hemisphere, lateral surface (see Fig 2 for reference)
1 5, 85, −45 501 2.398 2.651
2 −13, 78, −32 37 3.050 3.134
3 −14, 88, −17 65 2.039 2.323
4 −20, 73, −3 206 1.860 2.116
5 −12, 76, 13 69 2.527 2.796
6 −12, 38, −42 175 3.350 3.652
7 −14, 37, −16 154 2.271 2.434
8 −22, 3, 43 22 1.389 1.557
9 11, 28, 61 57 2.164 2.522
10 −40, −4, 15 232 2.569 2.817
11 −33, −21, 31 152 2.293 2.507
Right hemisphere, medial surface (see Fig 3 for reference)
1 −32, 82, 0 116 2.250 2.516
2 −31, 62, 26 131 2.347 2.510
3 −31, 40, 40 139 2.336 2.664
4 −31, 15, 38 67 2.187 2.450
5 2, 11, −64 159 3.342 3.970
6 −29, −57, 18 72 2.536 2.724
7 −25, −93, −19 204 1.571 1.797
8 17, −44, −52 65 2.697 2.928
Left hemisphere, medial surface (see Fig 4 for reference)
1 28, 93, −39 179 2.288 2.668
2 33, 51, 24 55 2.063 2.509
3 30, 41, 49 40 2.769 2.929
4 28, 13, 66 44 2.407 2.747
5 28, −68, 25 67 2.411 2.614
6 28, −63, 17 43 2.634 2.769
7 20, −102, −28 155 1.685 1.826
8 −4, −3, −64 558 3.012 3.470