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Tumor pathologic features by WHO grade, age, location, and rTBF
Tumor Pathologic Feature WHO Grade Mean Age^a Tumor Location rTBF^b
High-grade tumors (III and IV) (n=21) 
    Glioblastoma (4) IV 13 ± 8.5 Cerebrum 3.70 ± 1.89
    Anaplastic astrocytoma (1) III 11 Cerebrum 3.60
    CNS PNET (1) IV 9 Thalamus 1.32
    Medulloblastoma (9) IV 6.1 ± 3.7 PF 2.87 ± 1.74
    Primary malignant melanoma (1) IV 12 Cerebrum 1.70
    Anaplastic ependymoma (2) III 3 ± 2.8 PF 1.99 ± 0.39
    CNS ATRT (1) IV 4 Cerebrum 1.67
    Choroid plexus carcinoma (1) III 3 months Lateral ventricle 7.96
    DIPG (1) III 7 Pons 1.70
Low-grade tumors (I and II) (n=32) 
    Pilocytic astrocytoma (8) I 9.4 ± 6.1 Cerebrum (1), cerebellum (3), brain stem (4) 1.05 ± 0.19
    Hypothalamic astrocytoma (1) II 10 Hypothalamus–third ventricle 0.99
    Angiocentric glioma (1) I 15 Cerebrum 0.94
    DNT (2) I 5.5 ± 4.9 Cerebrum 0.89 ± 0.13
    OPG (4) I 4.8 ± 1.5 Optic chiasm 0.80 ± 0.09
    Choroid plexus papilloma (3) I 5.6 ± 3.5 PF (2), lateral ventricle (1) 1.13 ± 0.15
    Atypical choroid plexus papilloma (1) II 2 PF 1.34
    Ganglioglioma (6) I 6.2 ± 6.6 Cerebrum (5), brain stem (1) 1.45 ± 0.54
    Craniopharyngioma (4) I 12.8 ± 4.3 Suprasellar cistern 0.99 ± 0.13
    Atypical meningioma (1) II 8 months Cerebrum 1.60
    Ependymoma (1) II 3 PF 1.82
Unspecified grade (n=1) 
    DIPG (1) II–IV 6 Pons 1.35
Note:—ATRT indicates atypical teratoid rhabdoid tumor; PF, posterior fossa; PNET, primitive neuroectodermal tumor.
↵a Age in years, unless otherwise specified.
↵b rTBF equals the averaged maximal rTBF values from 2 different ROIs within the solid tumor.