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Relative change in FA and MK from birth to 4 years 7 months at all anatomic locations
Anatomic Location FA MK
R^2a % Δ (Birth to 2 yr)^b % Δ (Birth to 4 yr 7 mo)^c 90% of FA_max (mo)^d R^2a % Δ (Birth to 2 yr)^b % Δ (Birth to 4 yr 7 mo)^c 90% of MK_max (mo)^d
Splenium 0.66 70 71 9 0.82 157 165 15
Genu 0.63 81 89 16 0.85 115 129 19
Frontal WM 0.69 172 173 8 0.92 233 265 23
Parietal WM 0.77 111 116 13 0.94 236 257 19
Anterior IC 0.62 103 103 6 0.85 182 184 10
Posterior IC 0.61 48 48 4 0.84 158 159 9
EC 0.59 63 63 5 0.87 160 174 18
Thalamus 0.45 63 66 10 0.78 136 137 8
Putamen 0.03 −7 −18 N/A 0.68 80 81 8
Note:—NA indicates not applicable; EC external capsule.
a Coefficient of determination (R²) demonstrating the goodness of exponential fit for the FA and MK nonlinear monoexponential regression curves.
↵b Percentage change in FA and MK absolute values from birth to 2 years of age.
↵c Percentage change in FA and MK absolute values from birth to 4 years 7 months of age.
↵d Approximate age in months at which 90% of developmental plateau is reached since birth for both FA and MK datasets (ie, FA_max and MK_max).