Table 4:

Linear regression analysis including diffusion tensor imaging measures, T2 lesion burden, white matter, and cortical volumes in relapsing-remitting MS

	T1-LV	T2-LV	NWMV	NCV
FA, Total SDGM	−0.180	−0.094	0.096	0.221^*
β, P value	.052	.331	.273	.013^*
Caudate	−0.118	0.056	0.291^*	−0.147
β, P value	0.230	0.583	0.001^*	0.120
Thalamus	−0.130	0.068	0.101	0.176
β, P value	.177	.496	.250	.054
Hippocampus	−0.242^*	−0.295^*	0.084	0.376^*
β, P value	.010^*	.001^*	.360	<.001^*
MD, Total SDGM	0.270^*	0.206^*	−0.415^*	0.003
β, P value	.002^*	.015^*	<.001^*	.979
Caudate	0.282^*	0.142	−0.471^*	0.050
β, P value	.002^*	.115	<.001^*	.605
Thalamus	0.268^*	0.125	−0.370^*	−0.058
β, P value	.003^*	.167	<.001^*	.553
Hippocampus	0.227^*	0.304^*	−0.230^*	−0.063
β, P value	.014^*	<.001^*	.006^*	.526
AD, Total SDGM	0.225^*	0.179^*	−0.389^*	0.050
β, P value	.010^*	.037^*	<.001^*	.591
Caudate	0.280^*	0.156	−0.458^*	0.043
β, P value	.002^*	.076	<.001^*	.653
Thalamus	0.246^*	0.131	−0.361^*	−0.018
β, P value	.006^*	.139	<.001^*	.867
Hippocampus	0.175	0.240^*	−0.226^*	0.026
β, P value	.058	.006^*	.006^*	.807
RD, Total SDGM	0.296^*	0.222^*	−0.428^*	−0.028
β, P value	<.001^*	.008^*	<.001^*	.785
Caudate	0.282^*	0.133	−0.476^*	0.053
β, P value	.002^*	.140	<.001^*	.583
Thalamus	0.280^*	0.120	−0.372^*	−0.081
β, P value	.002^*	.190	<.001^*	.408
Hippocampus	0.252^*	0.334^*	−0.227^*	−0.113
β, P value	.006^*	<.001^*	.006^*	.230

Note:—NCV indicates normalized cortical volume; NWMV, normalized white matter volume; T1-LV, T1 lesion volume; T2-LV, T2 lesion volume.
Regression analysis was adjusted for the effects of age, sex, disability level, and disease duration. All P values were corrected for multiple comparisons using Benjamini-Hochberg correction.
↵* indicates significant P values (P < .05) after correction.