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Table 1:

Demographic, clinical, and conventional MRI characteristics of healthy control patients and patients with MS

HC (n = 110)MS (n = 285)RRMS (n = 210)PMS (n = 75)P Value
Age (y), mean (SD) median47.0 (12.9) 5046.9 (8.2) 480.96546.1 (8.5) 4649.2 (6.5) 50.006*
Sex, female, n (%)76 (69.1)206 (72.3)0.329149 (70.9)57 (78).496
Disease duration (y), mean (SD) medianNA14.4 (9.1) 1313.2 (8.8) 1217.9 (9.2) 18<.001*
EDSS, mean (SD) medianNA3.4 (1.9) 3.02.6 (1.5) 2.55.4 (1.5) 6.0<.001*
T2-LV, mean (SD) median0.3 (1.2) 013.5 (16.1) 7.3<.001*11.0 (13.5) 6.720.4 (20.4) 13.2.001*
T1-LV, mean (SD) median03.3 (6.5) 1.0NA2.7 (6.1) 0.85.1 (7.2) 1.7.037*
T1-Gd-LV mean (SD) medianNA0.05 (0.02) 0NA0.06 (0.4) 00.01 (0.02) 0.046*
  • Note:—EDSS indicates Expanded Disability Status Scale; LV, lesion volume; NA, not available; SD, standard deviation.

  • Statistical analysis among groups was performed with the Student t test, test, the Mann-Whitney U test and the χ2 test. All P values were corrected for multiple comparisons with use of Benjamini-Hochberg correction.

  • The volumes are expressed in milliliters.

  • * indicates significant P values (P < .05) after correction.