1naresh
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Study Sample Methods (Device/FS/TR/TE/Sequence) Region-of-Interest Voxel Size and Location Findings Cecil et al, 200369 9 Patients with euthymic mood disorder with at least 1 parent with BD, medicated (n = 1), unmedicated (n = 8), (mean age, 9.9 yr), Signaa/1.5T/2000/35/PRESS 8 mL in the cerebellar vermis, ↑ mIns/tCre levels in patients with mood disorder in the medial frontal cortex (16%); 8 mL in the medial frontal cortex, ↓ NAA/tCre in patients with mood disorder in the cerebellar vermis (8%); 10 healthy volunteers, (mean age, 10.6 yr) 8 mL in frontal lobe white matter no significant differences in NAA/tCre, tChol/tCre, or mIns/tCre in frontal lobe white matter Gallelli et al, 200584 60 Offspring of parents with BD, 32 patients with BD, medicated (n = 28), unmedicated (n = 4), (mean age, 14.1 yr), Signa/3T/2000/35/ PRESS 8 mL in the left and right dorsolateral prefrontal cortices No significant group difference in NAA/tCre in the left (P = .99) or right (P = .75) dorsolateral prefrontal cortex; 28 patients with subsyndromal BD symptoms, medicated (n = 20), unmedicated (n = 8), (mean age, 12.2 yr), mood state not reported, though “most subjects were not experiencing a manic or depressive episode at the time of scan,” 26 unaffected controls, (mean age, 14.2 yr) no significant group difference in mIns/tCre in the left (P = .15) or right (P = .19) dorsolateral prefrontal cortex; no significant group difference in tChol/tCre in the left (P = .31) or right (P = .46) dorsolateral prefrontal cortex Singh et al, 201085 20 Patients with euthymic BD, medicated (n = 17), unmedicated (n = 3), (mean age, 15.9 yr), Signa/3T/2000/35/ PRESS 8 mL in the anterior cingulate cortex ↓ Glu in BD compared with both healthy volunteers (P < .04) and subsyndromal BD (P < .04); 20 euthymic patients with subsyndromal BD, medicated (n = 17), unmedicated (n = 3), (mean age, 12.9), no significant group differences in NAA or mIns 20 healthy volunteers, (mean age, 15.1 yr) Singh et al, 201186 22 Euthymic youth at risk for BD with a parent with BD, medicated (n = 17), unmedicated (n = 5), psychostimulants discontinued 24 hours prior to scan, (mean age, 13.3 yr), Signa/3T/2000/35/PRESS 8 mL in the cerebellar vermis ↓ mIns in children at risk for BD (P < .01); 25 healthy volunteers, (mean age, 13.5 yr) ↓ tChol in children at risk for BD (P < .01) Wozniak et al, 201287 24 Euthymic youth at risk for BD, with a parent with BD, medicated (n = 11), unmedicated (n = 13), (mean age, 11.8 yr), Varianb/4T/2000/30/PRESS 8 mL in the anterior cingulate cortex Positive correlation between emotional dysregulation score and Glu (Pearson correlation = 0.659; P < .02) 13 healthy volunteers (mean age, 11.5 yr)