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Table 3: Common neurotransmitter systems studied in PET imaging and radioligands used for each component or pathway involved
Neurotransmitter System Component/Pathway Involved Radioligands Used
Serotonin Synthesis α-[¹¹C]MTrp
Transport [¹¹C]McNeil 5652
[¹¹C]DASB
Type 1A receptor [¹¹C]WAY-100635
[¹⁸F]FCWAY
[¹⁸F]MPPF
Type 1B receptor [¹¹C]P943
Type 2 receptor [¹⁸F]setoperone
[¹⁸F]altanserin
[¹¹C]MDL 100907
[¹⁸F]FESP
Dopamine Synthesis [¹⁸F]fluoro-L-DOPA
D1 receptor [¹¹C]SCH 23,390
[¹¹C]NNC 112
D2/3 receptor [¹¹C]raclopride
[¹¹C]FLB 457
Transporter [¹¹C]RTI-32
[¹¹C]CFT
Monoamine oxidase Monoamine oxidase type A [¹¹C]harmine
Non-monoaminergic mechanisms Muscarinic type 2 receptor [¹⁸F]FP-TZTP
Nicotinic receptor [¹⁸F]FA-85380
GABA type A receptor [¹¹C]flumazenil
Phosphodiesterase type 4 [¹¹C]-(R)-rolipram
Amyloid and τ proteins [¹⁸F]DDNP
p-glycoprotein [¹¹C]verapamil
Histamine H1 receptor [¹¹C]doxepin