Table 3:

Regional analysis of GM volume^{^a}

Region	GM Volume (% of TIV)
	HC		MCI		AD		F2, 27	Sig.
	Mean	SD	Mean	SD	Mean	SD	F2, 27	Sig.
Temporal lobe
Hippocampus R	.120^{^b,^d}	.004	.104^{^c,^d}	.016	.099^{^b,^c}	.010	8.3	<.005
Hippocampus L	.105^{^d}	.005	.096^{^d}	.016	.075^{^b,^c}	.012	15.3	<.001
Parahippocampal and ambient gyri R	.173^{^d}	.012	.168	.018	.151^{^c}	.013	5.7	<.01
Parahippocampal and ambient gyri L	.180^{^d}	.008	.173	.022	.158^{^c}	.015	4.2	<.05
Anterior TL lateral part R	.135	.018	.123	.018	.119	.017	2.2	NS
Anterior TL lateral part L	.118	.015	.111	.016	.101	.016	2.8	NS
Anterior TL medial part R	.272^{^d}	.022	.251	.025	.227^{^c}	.035	6.6	<.01
Anterior TL medial part L	.254	.028	.241	.029	.210	.046	3.9	<.05
Posterior TL R	1.35	.086	1.32	.115	1.25	.096	2.5	NS
Posterior TL L	1.32^{^d}	.086	1.26	.136	1.18^{^c}	.119	3.4	<.05
Insula and cingulate gyri
Insula R	.414^{^d}	.025	.378	.048	.365^{^c}	.029	5.0	<.05
Insula L	.432^{^d}	.030	.395	.057	.370^{^c}	.031	5.3	<.05
Anterior cingulate R	.272	.027	.270	.030	.282	.019	.49	NS
Anterior cingulate L	.282	.033	.272	.029	.274	.020	.42	NS
Posterior cingulate R	.261	.029	.264	.017	.266	.023	.09	NS
Posterior cingulate L	.273	.028	.270	.024	.275	.021	.12	NS
Frontal lobe
Middle frontal gyrus R	1.19	.065	1.13	.089	1.11	.093	2.5	NS
Middle frontal gyrus L	1.13^{^c}	.063	1.08	.119	1.02^{^c}	.091	3.3	.05
Medial orbitofrontal R	.184	.013	.159	.042	.156	.035	2.3	NS
Medial orbitofrontal L	.195	.014	.181	.031	.166	.036	2.6	NS
Subgenual anterior cingulate R	.039	.005	.036	.015	.046	.016	.01	NS
Subgenual anterior cingulate L	.046	.006	.046	.009	.046	.016	.24	NS
Parietal/occipital lobe
Cuneus R	.271	.031	.246	.051	.243	.064	1.0	NS
Cuneus L	.292	.029	.273	.043	.257	.063	1.4	NS
Superior parietal lobe R	1.04	.111	.866	.265	.853	.217	2.4	NS
Superior parietal lobe L	1.02	.089	.977	.095	.847	.211	4.2	<.05
Inferolateral parietal lobe R	1.07	.099	1.04	.098	1.01	.079	1.1	NS
Inferolateral parietal lobe L	1.07	.086	1.04	.114	.968	.080	2.6	NS
Central structures
Thalamus R	.186	.019	.177	.024	.180	.024	.50	NS
Thalamus L	.199	.026	.199	.026	.194	.022	.01	NS
Caudate R	.170	.019	.160	.021	.161	.020	.86	NS
Caudate L	.160	.029	.157	.026	.153	.015	.16	NS
Putamen R	.155	.019	.146	.030	.147	.025	.41	NS
Putamen L	.167	.019	.160	.028	.162	.022	.29	NS

Note:—HC indicates healthy controls; NS, not significant; Sig., Significance; R, right; L, left; TL, temporal lobe; TIV, total intracranial volume.
↵a Superscript letters indicate significant pair-wise comparisons revealed by post hoc testing (Tamhane T2, P = .05).
↵b Significantly different from MCI.
↵c Significantly different from HC.
↵d Significantly different from AD.