Multivariable logistic regression analysis of factors independently associated with a poor 90-day outcome

Independent Variable	Model 1^{^a}	P Value	Model 2^{^b}	P Value	Model 3^{^c}	P Value	Model 4^{^d}	P Value
Severe leukoaraiosis^{^e}	6.50 (2.11–20.06)	<.001	4.40 (1.22–15.74)	.023	6.03 (1.80–22.11)	.004	6.37 (1.83–12.18)	.004
Admission NIHSS score	–	–	1.08 (1.00–1.16)	.027	1.09 (1.01–1.17)	.023	1.08 (1.00–1.16)	.041
Age (yr)	–	–	1.03 (0.99–1.07)	.065	1.03 (1.00–1.07)	.028	1.03 (0.99–1.06)	.005
LDL	–	–	0.98 (0.97–1.00)	.057	0.98 (0.97–1.00)	.014	0.99 (0.97–1.00)	.064
Creatinine level	–	–	–	–	3.21 (0.78–13.19)	.105	–	–
Poor recanalization	–	–	–	–	3.72 (1.10–12.53)	.034	2.94 (0.84–10.21)	.089
Parenchymal hemorrhage	–	–	–	–	–	–	3.23 (1.01–10.37)	.049

Note:— – indicates not applicable; LDL, low-density lipoprotein. Factors that were not included in the final model iteration are omitted from the table. Data are odds ratios with 95% confidence intervals.
↵a Model 1, unadjusted.
↵b Model 2, adjusted for age, admission NIHSS score, atrial fibrillation, creatinine level, LDL, and random blood sugar (Hosmer-Lemeshow statistics: χ² = 6.047, P = .642).
↵c Model 3, additionally adjusted for collateral grade, degree of recanalization, and time to recanalization (Hosmer-Lemeshow statistics: χ² = 9.856, P = .275).
↵d Model 4, adjusted for model 3 plus the presence of parenchymal hemorrhagic transformation (Hosmer-Lemeshow statistics: χ² = 3.418, P = .905).
↵e The association with outcome remained when leukoaraiosis, degree of recanalization, and collateral grade were entered as ordinal variables (P < .01).