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Table 2: Validation of the previously described model combining clinical and imaging thresholds to predict outcome in acute ischemic stroke
Threshold Positive Predictive Value (%) Prognostic Yield (%)
Poor outcome 
    DWI > 70 mL 86.4^{^a} 17.9
    NIHSS score > 20 100.0^{^a} 11.4
Good outcome 
    MTT < 0 mL 89.5^{^a} 30.9
    Tmax < 50 mL 88.9^{^a} 29.3
    NIHSS score < 8 92.3^{^a} 31.7
Combined clinical thresholds (NIHSS score) 94.3^{^a} 43.1
Combined imaging thresholds (DWI + MTT) 88.3^{^a} 48.8
Combined imaging thresholds (DWI + Tmax > 6 seconds) 87.9^{^a} 47.2
Combined clinical and imaging thresholds 88.8^{^a} 65.0^{^b}
↵a No significant difference in PPV between any of the applied thresholds.
↵b Significantly increased over use of single parameters (P < .0001) and combined clinical or imaging thresholds (P = .01).

Threshold	Positive Predictive Value (%)	Prognostic Yield (%)
Poor outcome
DWI > 70 mL	86.4^{^a}	17.9
NIHSS score > 20	100.0^{^a}	11.4
Good outcome
MTT < 0 mL	89.5^{^a}	30.9
Tmax < 50 mL	88.9^{^a}	29.3
NIHSS score < 8	92.3^{^a}	31.7
Combined clinical thresholds (NIHSS score)	94.3^{^a}	43.1
Combined imaging thresholds (DWI + MTT)	88.3^{^a}	48.8
Combined imaging thresholds (DWI + Tmax > 6 seconds)	87.9^{^a}	47.2
Combined clinical and imaging thresholds	88.8^{^a}	65.0^{^b}