Table 2:

Survival analysis of MRI features for patients with solitary ISCMs (n = 39)

Variable	Median Survival (days^{^a}) (95% CI)	Hazard Ratio (95% CI)	P Value^{^b}
No. of ISCMs			.022
Solitary (n = 39)	121 (42–187)	–
Multiple (n = 10)	53 (12–88)	–
Noncord CNS/spinal metastases			.879
No (n = 19)	166 (87–334)	–
Yes (n = 20)	79 (26–184)	–
Leptomeningeal metastases			.274
No (n = 27)	127 (38–231)	–
Yes (n = 12)	113 (24–790)	–
Primary tumor/non-CNS metastases			.012
No (n = 15)	316 (38–790)	–
Yes (n = 24)	96 (32–166)	–
Cord T2 hyperintensity ≥2 segments^{^c}			.037
No (n = 10)	184 (24–884)	–
Yes (n = 28)	111 (38–166)	–
Cord T2 hyperintensity ≥3 segments^{^c}			.018
No (n = 12)	184 (24–790)	–
Yes (n = 26)	111 (38–166)	–
Cord T2 hyperintensity (No. of segments)^{^c} (n = 38)	121 (42–187)	1.02 (0.96–1.09)	.541
ISCM enhancement, superoinferior size (mm)^{^c} (n = 35)	120 (42–187)	1.01 (0.99–1.02)	.138
ISCM enhancement, extent (No. of vertebral segments)^{^c} (n = 35)	120 (42–187)	1.08 (0.85–1.38)	.524
Ratio, longitudinal extent of cord T2 hyperintensity to enhancement^{^c} (n = 34)	119 (40–187)	1.03 (0.94–1.13)	.477
Rim sign^{^c}			.621
No (n = 18)	79 (26–643)	–
Yes (n = 17)	127 (40–299)	–
Flame sign^{^c}			.068
No (n = 19)	127 (42–734)	–
Yes (n = 16)	96 (26–299)	–
Rim/flame signs^{^c}			.143
Neither (n = 13)	121 (32–884)	–
Rim sign only (n = 6)	147 (21–790)	–
Flame sign only (n = 5)	26 (15–643)	–
Both signs (n = 11)	120 (38–316)	–

Note:— – indicates not applicable.
↵a From date of ISCM diagnosis.
↵b P values are for log-rank tests for categoric variables and Wald tests for continuous variables.
↵c Missing patients (n < 39) due to MRI not having sagittal T2- or gadolinium-enhanced sagittal T1-weighted images.