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Table 1: Comparing demographics/clinical factors between patients with positive SPAN-100 and patients with negative SPAN-100
SPAN-100-Negative (n = 218) SPAN-100-Positive (n = 55) P Value
Age (yr) 68.2 ± 12.5 85.5 ± 5.07 <.001
NIHSS (median, IQR) 13 (7–18) 21 (17–24) <.001
Male sex 121 (55.5%) 22 (40) .04
SBP 157.7 (139–172) 156.04 (138–177) .77
DBP 84.9 (71–95) 76.1 (64–87) .01
Glucose (admission) 8.1 (5.8–8.1) 7.6 (6.0–9.0) .18
Risk factors 
    Hypertension 127 (58.26) 45 (81.8) .001
    Diabetes mellitus 43 (19.72) 10 (18.18) .79
    Hypercholesterolemia 72 (33.03) 25 (45.4) .08
    Coronary artery disease 53 (24.3) 12 (21.8) .69
    Atrial fibrillation 64 (29.36) 19 (34.5) .45
    Smoker 44 (20.1) 6 (10.9) .11
    Stroke 1 (0.46) 1 (1.82) .29
    Hyperdense sign 114 (52.53) 35 (63.64) .13
    ASPECTS (median) (IQR) 7 (6–9) 7 (5–8) .39
    Clot burden score 6 (4–9) 6 (5–9) .29
    Collateral score 2 (2–3) 2 (1–2) <.001
    CBV (median) (IQR) 14.7 (4.7–34.7) 34.7 (13.8–60.5) <.001
    CBF 101.6 (55.3–133.1) 98.2 (74.6–129.5) .75
    MTT 104.5 (58.5–133.4) 98.4 (74.7–130.5) .69
Time and thrombolysis 
    rtPA dose 63.0 (54–73) 63.0 (54–72) .75
    Onset to CT 104.0 (80–148) 108.0 (75–127) .62
    Onset to rtPA 161.7 (147) 143.0 (131) .03
Outcome 
    Recanalization 119 (55.35) 33 (61.1) .44
    mRS (at follow-up) 3 (1–4) 5 (4–6) <.001
    mRS ≤ 2 92 (42.2) 6 (10.9) <.001
    NIHSS improves >3 in 24 hours 101 (46.3) 27 (49) .71
    Hemorrhagic transformation 78 (38.6) 28 (56.0) .02
    Hemorrhage infarct 64 (29.4) 23 (41.8) .07
    Parenchymal hemorrhage 26 (11.9) 9 (16.4) .37
Note:—IQR indicates interquartile range; SBP, systolic blood pressure; DBP, diastolic blood pressure.