Demographic and clinical characteristics of healthy controls and patients with active, remitted, and cured CS^{^a}

	Healthy Controls	Patients with Active CS	Patients with Remitted CS	Patients with Cured CS	F/χ²	P Value
Age (yr)	42.3 ± 10.4	41.9 ± 8.7	47.1 ± 10.0	41.4 ± 10.0	5.9	NS
Sex (M/F)	6:29	1:7	1:6	4:16	0.3	NS
Years of education	13.5 ± 3.4	14.4 ± 3.0	12.9 ± 2.3	13.4 ± 3.1	0.3	NS
24-Hour urinary free cortisol	133 ± 52	543 ± 307	152 ± 74	122 ± 75	26.3	<.001^{^b}
Smoking status (nonsmoker/smoker/ex-smoker)	12/12/11	7/1/0	2/4/1	9/5/6	10.4	NS
Disease duration (mo)	NA	77.6 ± 77.4	44.6 ± 21.9	64.6 ± 34.0	0.99	NS
Origin (pituitary/adrenal/ectopic/AIMAH)	NA	5/3/0/0	3/2/1/1	17/2/0/0	10.8	NS
Hypertension (no/yes)	35/0	4/4	3/4	13/7	20.9	<.001^{^c}
Hypercholesterolemia (no/yes)	31/4	7/1	7/0	17/3	1.2	NS
Hypertriglyceridemia (no/yes)	29/6	6/2	3/4	9/11	10.5	.015^{^d}
Central obesity (no/yes)	25/10	2/6	0/7	9/11	15.6	.001^{^e}
Body mass index^{^g} (no/overweight/obesity)	22/11/2	2/5/1	1/3/3	8/9/3	12.6	.049^{^f}

Note:—NS indicates not significant; AIMAH, ACTH-independent macronodular adrenal hyperplasia.
↵a Data are expressed as mean ± SD.
↵b Healthy controls vs active CS (<.001); active CS vs remitted CS (<.001); active CS vs cured CS (<.001).
↵c Healthy controls vs active CS (<.001); healthy controls vs remitted CS (<.001); healthy controls vs cured CS (<.001).
↵d Healthy controls vs remitted CS (.043); healthy controls vs cured CS (.006).
↵e Healthy controls vs active CS (.015); healthy controls vs remitted CS (.001).
↵f Healthy controls vs remitted CS (.015).
↵g Body mass index: normal, ≤25; overweight, 25–30; obesity, >30.