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Table 2: Pearson correlation coefficients between method differences in total volume estimation and WML size^{^a}
Method GM WM CSF
H1 
    ANN 0.94 −0.90 0.89
    FCM 0.93 −0.89 0.83
    FANTASM 0.87 −0.80 0.78
    FAST 0.97 −0.97 0.96
    SPM5 0.58^{^b} −0.89 −0.21^{^b}
    SPM8 0.92 −0.63 −0.69
H2 
    ANN 0.91 −0.88 0.93
    FCM 0.92 −0.94 0.92
    FANTASM 0.89 −0.87 0.84
    FAST 0.95 −0.96 0.82
    SPM5 −0.35^{^b} −0.06^{^b} 0.72
    SPM8 0.76 −0.79 0.57^{^b}
H3 
    ANN 0.56^{^b} −0.55^{^b} 0.88
    FCM 0.77 −0.84 0.88
    FANTASM 0.74 −0.82 0.85
    FAST 0.88 −0.94 0.92
    SPM5 −0.06^{^b} −0.03^{^b} 0.21^{^b}
    SPM8 0.56^{^b} −0.48^{^b} 0.09^{^b}
↵a Correlation was computed for each method and hospital separately. All values were found to be significant (P value < .05) unless otherwise noted.
↵b Not significant.

Method	GM	WM	CSF
H1
ANN	0.94	−0.90	0.89
FCM	0.93	−0.89	0.83
FANTASM	0.87	−0.80	0.78
FAST	0.97	−0.97	0.96
SPM5	0.58^{^b}	−0.89	−0.21^{^b}
SPM8	0.92	−0.63	−0.69
H2
ANN	0.91	−0.88	0.93
FCM	0.92	−0.94	0.92
FANTASM	0.89	−0.87	0.84
FAST	0.95	−0.96	0.82
SPM5	−0.35^{^b}	−0.06^{^b}	0.72
SPM8	0.76	−0.79	0.57^{^b}
H3
ANN	0.56^{^b}	−0.55^{^b}	0.88
FCM	0.77	−0.84	0.88
FANTASM	0.74	−0.82	0.85
FAST	0.88	−0.94	0.92
SPM5	−0.06^{^b}	−0.03^{^b}	0.21^{^b}
SPM8	0.56^{^b}	−0.48^{^b}	0.09^{^b}