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Table 1: Common Terminology Criteria for Adverse Events, Version 4.0: central nervous system necrosis^{^a}
Grade Criteria
1 Asymptomatic; clinical, or diagnostic observations only; intervention not indicated
2 Moderate symptoms; corticosteroids indicated
3 Severe symptoms; medical intervention indicated
4 Life-threatening consequences; urgent intervention indicated
5 Death
↵a Adapted from Department of Health and Human Services.¹⁵

Grade	Criteria
1	Asymptomatic; clinical, or diagnostic observations only; intervention not indicated
2	Moderate symptoms; corticosteroids indicated
3	Severe symptoms; medical intervention indicated
4	Life-threatening consequences; urgent intervention indicated
5	Death