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Table 3: Intrareader agreement demonstrated with binary groupings of new and improved lesions using both conventional side-by-side comparison and the software^{^a}
New Lesions (κ) (95% CI) Improved Lesions (κ) (95% CI)
One or more lesions 
    VTS 1st vs VTS 2nd read 1.000 0.937 (0.815–1.000)
    CSSC 1st vs CSSC 2nd read 0.941 (0.826–1.000) 0.462 (0.039–0.886)
Two or more lesions 
    VTS 1st vs VTS 2nd read 1.000 0.731 (0.448–1.000)
    CSSC 1st vs CSSC 2nd read 0.846 (0.640–1.000) 0.482 (−0.118–1.000)
Three or more lesions 
    VTS 1st vs VTS 2nd read 1.000 0.774 (0.472–1.000)
    CSSC 1st vs CSSC 2nd read 0.724 (0.361–1.000) 0.482 (−0.118–1.000)
↵a Correlations demonstrated substantial intrareader agreement. The software generally outperformed conventional side-by-side comparison without, however, reaching statistical significance.