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Demographic, transplant, and Loes characteristics in higher risk patients with cALD (Loes ≥10) analyzed for neurologic function change by pretransplantation gadolinium intensity score
GIS 0/1 (n = 7) GIS 2/3 (n = 18) Difference (95% CI)
Age at HSCT (yr) 
    Mean 10.1 9.0 1.2 (−1.9–4.2)
    IQR 8.1–13.3 6.8–10.0 
Pre-HSCT Loes 
    Mean 12.6 14.0 −1.5 (−3.3–0.4)
    IQR 11–14 11–16 
Donor chimerism (%)^{^a} 
    Mean 98.7 97.1 1.6 (−2.1–5.3)
    IQR 100–100 92–100 
Note:—IQR indicates interquartile range.
↵a Donor chimerism reflects the percentage of donor hematopoietic engraftment at the most recent follow-up.

	GIS 0/1 (n = 7)	GIS 2/3 (n = 18)	Difference (95% CI)
Age at HSCT (yr)
Mean	10.1	9.0	1.2 (−1.9–4.2)
IQR	8.1–13.3	6.8–10.0
Pre-HSCT Loes
Mean	12.6	14.0	−1.5 (−3.3–0.4)
IQR	11–14	11–16
Donor chimerism (%)^{^a}
Mean	98.7	97.1	1.6 (−2.1–5.3)
IQR	100–100	92–100