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Table 2: Univariate and multivariate Cox survival analysis of clinical variables
Univariate Cox Multivariate Cox
HR (95% CI) P Value HR (95% CI) P Value
TCGA test cohort^{^a} 
    Age younger than 64 yr 0.19 (0.26–0.55) 4.1e–7^{^b} 0.36 (0.24–0.53) 3.7e–7^{^b}
    Male sex 1.05 (0.73–1.50) .79 – –
    CEL tumor volume (cm³) 
        Large 1.68 (1.10–2.54) .015^{^b} 1.80 (1.18–2.75) .0064^{^b}
        Intermediate – – – –
        Small 0.90 (0.58–1.37) .62 1.11 (0.71–1.71) .65
    Right laterality 0.927 (0.65–1.32) .67 – –
    STR 2.52 (0.73–8.68) .14 – –
    Tumor location = right periatrial location 1.66 (1.03–2.67) .036^{^b} 2.0 (1.01–2.64) .045^{^b}
Restricted set of intermediate and large tumors^{^c} 
    Age younger than 64 yr 0.19 (0.26–0.55) 4.1e–7 0.46 (0.30–0.72) .00062
    Tumor location = right periatrial location 1.84 (1.10–3.08) .019 1.87 (1.11–3.15) .018
Note:—HR indicates hazard ratio; STR, subtotal resection.
↵a Age, CEL tumor volume, and tumor location were independently significant in multivariate analysis (overall P < 3.52e–8). Surgical resection is subtotal resection or gross total resection, available for 24 cases in the TCGA test cohort.
↵b P value < .05, indicating the variable is significant.
↵c Tumor location remained significant in Cox analysis performed on the restricted set of intermediate and large tumors.