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Table 3: DTI and volumetric variables of baseline and month 12 visit (mean)
Baseline Month 12 P Value
Patients on natalizumab (n = 22) 
    FA severity (z score) −0.67 ± 0.65 −0.59 ± 0.69 .02^{^a}
    MD severity (z score) 0.89 ± 0.92 0.93 ± 0.98 .81
    AD severity (z score) 0.36 ± 0.40 0.43 ± 0.39 .34
    RD severity (z score) 0.94 ± 1.00 0.94 ± 1.07 1.0
    NGMV (L) 0.75 ± 0.04 0.75 ± 0.05 1.0
    NWMV (L) 0.69 ± 0.04 0.67 ± 0.03 .008^{^a}
    NBV (L) 1.44 ± 0.06 1.42 ± 0.06 .036^{^a}
    T2 lesion volume (mL)^{^b} 6.2 (2.4–14.9) 6.9 (2.2–13.6) .644
Patients on IFNb/GA (n = 17) 
    FA severity (z score) −0.64 ± 0.43 −0.67 ± 0.48 .94
    MD severity (z score) 0.74 ± 0.58 0.78 ± 0.58 .64
    AD severity (z score) 0.26 ± 0.35 0.26 ± 0.28 1.0
    RD severity (z score) 0.82 ± 0.59 0.87 ± 0.62 .43
    NGMV (L) 0.73 ± 0.06 0.74 ± 0.05 1.0
    NWMV (L) 0.69 ± 0.04 0.67 ± 0.03 .004^{^a}
    NBV (L) 1.42 ± 0.08 1.41 ± 0.07 <.001^{^a}
    T2 lesion volume (mL)^{^b} 4.9 (0.25–12.0) 5.4 (0.28–13.3) .012^{^a}
Note:—NGMV indicates normalized gray matter volume; NWMV, normalized white matter volume.
↵a Significant difference between the time points (Bonferroni-corrected).
↵b Median and interquartile range.