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Table 2:

Description of selected agents used for injection laryngoplasty

AgentsLongevityImaging Findings
Hyaluronic acid gels (Restylane, Hylaform)TemporaryNearly fluid attenuation on CT; T1 hypointense and T2 hyperintense, similar to fluid on MRI; may display peripheral enhancement initially
Micronized cadaveric dermis (Cymetra)TemporaryT1 and T2 hyperintense within the first year of injection
Bovine collagen preparations (Zyplast)TemporaryGenerally fluid attenuation on CT; T1 hypointense and T2 hyperintense, similar to fluid on MRI; may display peripheral enhancement initially
Calcium hydroxylapatite (Radiesse Voice)Long-lastingHigh attenuation on CT (280–700 HU); hypermetabolic on 18FDG-PET
Autologous fatLong-lastingAttenuation and signal characteristics of adipose tissue
TeflonPermanentGlobular high attenuation on CT (200–400 HU range)