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Table 2: 
Linear regression models between age and ROI volumes (normalized by total intracranial volume) and SPARE-AD and SPARE-BAa
OutcomeAgeAge2FemaleAPOE ϵ4 Carriers
Lateral frontal volume−0.0003900 (<.001)b–0.0021720 (<.001)b−0.0002459 (.433)
Lateral temporal volume0.0001020 (.040)b−0.0000021 (<.001)b0.0003695 (.040)b0.0001112 (.605)
Medial frontal volume−0.0001291 (<.001)b–0.0010690 (<.001)b−0.0000055 (.964)
Hippocampal volume0.0000415 (<.001)b−0.0000005 (<.001)b0.0001919 (<.001)b0.0000118 (.649)
SPARE-AD−0.0438960 (<.001)b0.0006549 (<.001)b−0.1775256 (<.001)b0.0293579 (.582)
SPARE-BA−0.1062550 (<.001)b–0.6416590 (<.001)b−0.0514570 (.452)
  • ↵a If age2 was not significant in a model, the coefficients were recalculated after excluding. Data are coefficient (P value).
  • ↵b Significant at P < .05. Models are adjusted for education and study cohort effects. Including interaction terms between APOE status and age2, age, sex, and education one at a time to those regression models showed no significant interaction (P > .1).