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Table 2: Areas of significantly (P_uncorrected < .001) reduced cortical perfusion in RRMS subgroups and healthy controls, with volumes for atrophied regions added as covariates
qCBF qCBV Anatomic Regions Cluster Size MNI Coordinates t Values
x y z HC vs CI HC vs NI NI vs CI
✓ ✓ Left superior frontal gyrus (BAs 6, 10)^{^a} 78 −32 50 28 3.52 3.62
✓ Right middle frontal gyrus (BA 6)^{^a} 26 34 0 64 3.31 
✓ ✓ Left middle frontal gyrus (BAs 10, 11, 46)^{^a} 100 −22 56 26 4.79 4.56 3.21
✓ Left inferior frontal gyrus (BA 46) 21 −48 30 20 3.29
✓ Right parahippocampal gyrus (BA 28)^{^a} 27 24 −22 −12 4.15 
✓ ✓ Right lingual gyrus^{^a} 101 12 −72 −2 5.11
✓ Left lingual gyrus (BA 18) 72 −6 −68 2 3.99
✓ Right inferior parietal lobule (BA 40)^{^a} 22 48 −40 56 3.98
✓ Right superior temporal gyrus (BA 38) 38 28 10 −46 3.64 
✓ Left temporal fusiform gyrus (BA 20)^{^a} 134 −44 −22 −30 3.74
✓ Left caudate head^{^a} 36 −10 6 4 3.64
✓ Right caudate body 24 18 −20 26 3.68
✓ Left thalamic medial dorsal nuclei^{^a} 31 −6 −18 6 3.63
Note:—CI indicates patients with RRMS with cognitive impairment; NI, patients with RRMS without impairment; ✓, anatomic region was present in VBM analysis for this map.
↵a Anatomic regions remained significant from previous VBM analysis without atrophy areas added as covariates.