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Table 2:

Mean ± standard deviation of mean, SD, skewness, and kurtosis of T1 and T2 from various tumor regions and contralateral white matter in 3 tumor types with results from the Wilcoxon rank sum testa and the Wilcoxon signed rank testb

ROIParameterTissue TypeaAll Tissue Types Combined (n = 31)b
GBM (n = 17)cMetastasis (n = 8)cLGG (n = 6)
STMean1639 ± 247 (v MET P ≤ .05)1324 ± 273 (v LGG P ≤ .05)1600 ± 1971558 ± 271 (v CW P < .0063)d
T1SD133 ± 50116 ± 63120 ± 26126 ± 49 (v CW P < .0063)d
Skewness0.01 ± 0.660.38 ± 0.560.16 ± 0.520.12 ± 0.61
Kurtosis3.06 ± 0.963.23 ± 0.583.26 ± 1.113.14 ± 0.90
STMean138 ± 22 (v MET P ≤ .05)105 ± 27 (v LGG P < .0042)d172 ± 53137 ± 37 (v CW P < .0063)d
T2SD21 ± 917 ± 922 ± 1220 ± 9 (v CW P < .0063)d
Skewness0.77 ± 1.43 (v LGG P ≤ .05)0.67 ± 0.97−0.28 ± 0.680.54 ± 1.25
Kurtosis6.38 ± 8.615.49 ± 6.542.88 ± 0.615.47 ± 7.19
PWMean1578 ± 331 (v LGG P < .0042)d1382 ± 188 (v LGG P ≤ .05)1066 ± 2181429 ± 338 (v CW P < .0063)d
T1SD124 ± 59 (v LGG, MET P ≤ .05)75 ± 2773 ± 15101 ± 52 (v CW P < .0063)d
Skewness−0.06 ± 0.44 (v LGG P ≤ .05)−0.10 ± 0.39 (v LGG P ≤ .05)0.54 ± 0.560.04 ± 0.50
Kurtosis2.73 ± 0.812.84 ± 0.533.12 ± 0.972.83 ± 0.77 (v CW P ≤ .05)
PWMean140 ± 27 (v LGG P ≤ .05)119 ± 27 (v LGG P ≤ .05)102 ± 43127 ± 33 (v CW P < .0063)
T2SD17 ± 7 (v LGG, MET P ≤ .05)12 ± 710 ± 314 ± 7 (v CW P < .0063)
Skewness0.39 ± 1.51 (v LGG P ≤ .05)0.39 ± 0.85 (v LGG P ≤ .05)0.71 ± 0.530.45 ± 1.20
Kurtosis5.68 ± 11.824.99 ± 2.843.45 ± 1.405.07 ± 8.80
CWMean927 ± 133911 ± 39873 ± 61912 ± 104
T1SD40 ± 1144 ± 1236 ± 1040 ± 11
Skewness0.27 ± 0.510.45 ± 0.550.13 ± 0.690.29 ± 0.55
Kurtosis3.22 ± 1.133.09 ± 0.573.54 ± 1.323.25 ± 1.04
CWMean69 ± 972 ± 672 ± 1770 ± 11
T2SD5 ± 25 ± 16 ± 35 ± 2
Skewness0.20 ± 1.600.27 ± 0.950.58 ± 0.950.31 ± 1.33
Kurtosis4.85 ± 7.073.96 ± 2.073.82 ± 1.734.41 ± 5.32
  • Note:—v indicates versus (when compared to).

  • a When comparing tumor types by rank sum tests, P values < .0042 (0.05/12) were statistically significant after Bonferroni correction. P values labeled as P ≤ .05 have unadjusted P values ≤ .05 but are not statistically significant after Bonferroni correction.

  • b When comparing tumor tissue vs CW by signed rank tests, P values < .0063 (0.05/8) were statistically significant after Bonferroni correction.

  • c For solid tumor analysis for GBMs (n = 16) and for METs (n = 7) (see “ROI Analysis” in “Materials and Methods” for further details).

  • d P value statistically significant after Bonferroni correction.