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Table 2: Measurements of CVR, FA, MD, T2, and perfusion metrics in WMH and contralateral homologous NAWM
WMH (Contralateral to NAWM), Mean (SD) NAWM (Contralateral to WMH), Mean (SD) Paired Differences t-Score df
Mean (SD) 95% CI Difference
CVR (% BOLD/mm Hg) 0.05 (0.07) 0.13 (0.03) 0.06 (0.03) 0.05–0.07 14.8^{^a} 74
FA (unitless) 0.28 (0.07) 0.50 (0.11) 0.18 (0.04) 1.72–1.91 38.2^{^a} 74
MD (×10⁻³mm²/s) 1.37 (0.11) 0.84 (0.03) 0.51 (0.11) 0.48–0.54 40.7^{^a} 74
T2 (ms) 136.7 (14.4) 84.9 (4.9) 51.6 (11.8) 48.5–54.8 32.3^{^a} 53
CBF (mL/100 g/min) 18.2 (3.5) 21.0 (4.4) 1.9 (4.3) 0.16–3.7 2.8 (P = .01) 24
rCBV (AU)^{^b} 103.9 (10.1) 117.5 (9.3) 8.9 (19.7) 0.8–17.7 2.3 (P = .03) 24
MTT (s) 4.6 (0.5) 4.1 (0.3) 0.3 (1.1) −0.1–0.8 1.5 (P = .15) 24
Tmax (s) 3.5 (0.3) 2.4 (0.2) 1.1 (0.8) 0.8–1.2 6.8^{^a} 24
TTP (s) 22.3 (1.3) 20.8 (1.0) 1.6 (1.2) 1.1–2.1 6.7^{^a} 24
Note:—FA indicates fractional anisotropy; rCBV, relative CBV; Tmax, time-to-maximum; AU, arbitrary units.
↵a P < .001 compared with contralateral WMH.
↵b These arbitrary units indicate that WMH are reduced compared to contralateral NAWM by 10.2%