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Table 3: ROC analysis of individual and combined MRI modalities
AUC Sens Spec PPV NPV P Value^{^a}
C vs PD/MSA-P/PSP .013
    DTI+R2* 0.88 0.80 0.83 0.82 0.81 
    DTI^{^b} 0.80 0.81 0.71 0.60 0.87 
    R2* 0.75 0.69 0.69 0.55 0.81 
C vs PD .001
    DTI+R2* 0.91 0.86 0.80 0.82 0.89 
    DTI 0.82 0.74 0.76 0.75 0.76 
    R2* 0.78 0.71 0.75 0.71 0.74 
PD vs MSA-P/PSP .038
    DTI+R2* 0.94 0.86 0.87 0.88 0.84 
    DTI 0.89 0.83 0.80 0.82 0.81 
    R2* 0.87 0.87 0.77 0.87 0.77 
PD vs MSA-P .006
    DTI+R2* 0.99 0.97 1.00 1.00 0.93 
    DTI 0.89 0.83 0.86 0.79 0.86 
    R2* 0.91 0.86 0.86 0.94 0.70 
PD vs PSP .156
    DTI+R2* 0.99 0.97 1.00 1.00 0.94 
    DTI 0.97 0.94 0.94 0.97 0.89 
    R2* 0.87 0.80 0.83 0.82 0.81 
MSA-P vs PSP .435
    DTI+R2* 0.98 0.94 1.00 1.00 0.93 
    DTI 0.96 0.94 0.92 0.94 0.92 
    R2* 0.89 0.86 0.80 0.82 0.81 
Note:—Sens indicates sensitivity; Spec, specificity; PPV, positive predictive value; NPV, negative predictive value; AUC, area under the curve; C, controls.
↵a ROC curves were compared between the models, including all MRI measurements and that with DTI measurements only.
↵b Models for DTI measurements were generated by including both FA and MD features.