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Table 1: Neuropathologic details of postmortem brain tissue used in the study
Sex/Age at Death (yr) Postmortem Delay (hr) Age at Onset (yr)
SPMS cases 
    MS92 F/38 26 21
    MS121 F/49 24 36
    MS154 F/35 12 23
    MS160 F/44 18 29
    MS176 M/37 12 10
    MS180 F/44 9 26
    MS229 M/53 13 37
    MS230 F/42 31 22
    MS234 F/39 15 23
    MS286 M/45 7 29
    MS289 M/45 9 27
    MS317 F/48 21 18
    MS330 F/59 24 19
    MS356 F/45 10 28
    MS408 M/39 21 29
    MS517 F/48 12 23
Control cases 
    C14 F/64 18 
    C25 M/35 22 
    C28 F/60 13 
    C30 M/75 17 
    C36 M/68 30 
    C41 M/51 22 
    C48 M/68 10 
    C54 M/66 16

	Sex/Age at Death (yr)	Postmortem Delay (hr)	Age at Onset (yr)
SPMS cases
MS92	F/38	26	21
MS121	F/49	24	36
MS154	F/35	12	23
MS160	F/44	18	29
MS176	M/37	12	10
MS180	F/44	9	26
MS229	M/53	13	37
MS230	F/42	31	22
MS234	F/39	15	23
MS286	M/45	7	29
MS289	M/45	9	27
MS317	F/48	21	18
MS330	F/59	24	19
MS356	F/45	10	28
MS408	M/39	21	29
MS517	F/48	12	23
Control cases
C14	F/64	18
C25	M/35	22
C28	F/60	13
C30	M/75	17
C36	M/68	30
C41	M/51	22
C48	M/68	10
C54	M/66	16