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Clinical features, disease stage, final nodal size (relative to baseline CT), and patient outcome
Patient No. Lesion No. Age, yr Sex Stage BRAF Status Location Final Lesion Size Patient Outcome 1 1 63 F T3bN3M1a Negative Left supraclavicular Decreased Remission. 2 2 66 M TxNxM1c Wild type Right supraclavicular Decreased T-VEC discontinued after disease progression in ribs. Placed on nivolumab with partial response. 3 Right supraclavicular Decreased 3 4 40 M pT1bN3M1c Positive Right preauricular Decreased IL-2 followed by BRAF and MEK inhibitors after ipilimumab/T-VEC treatment. Deceased. 5 Right submandibular Decreased 4 6 44 M T3bN3M1b Positive Right axillary Decreased BRAF and MEK inhibitors after ipilimumab/T-VEC treatment, followed by disease progression. Deceased. 7 Right axillary Decreased 5 8 58 F T3bN2M1a Wild type Left upper back Decreased Complete response for 21 months, followed by axillary recurrence. Placed on nivolumab. 9 Left breast Decreased 6 10 32 M T4bN3M1a Negative Left retroauricular Decreased Partial response for 6 months. Placed on nivolumab. 7 11 63 M T3aN3M1c Negative Right chest wall Increased Rapid deterioration after brain metastases. Deceased. 12 Right axilla Decreased
Note:—IL-2 indicates interleukin 2.