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Table 1: Univariate analysis of IAUC histogram parameters as predictors of OS and PFS in the unmethylated and methylated MGMT subgroups.
Survival/Parameters Unmethylated MGMT (n = 51) Methylated MGMT (n = 37)
Cutoff Value HR (95% CI) P Value^{^a} Cutoff Value HR (95% CI) P Value^{^a}
OS 
    IAUC30_mean ≥10.9 3.04 (1.28–7.21) .008 ≥15.1 0.60 (0.17–2.14) .429
    IAUC60_mean ≥28.4 3.48 (1.20–10.14) .015 ≥32.0 0.42 (0.16–1.14) .079
PFS 
    IAUC30_mean ≥10.9 2.60 (1.23–5.50) .010 ≥15.1 0.52 (0.18–1.56) .238
    IAUC60_mean ≥32.6 2.15 (1.14–4.05) .015 ≥32.8 0.24 (0.22–1.28) .155
Note:—HR indicates hazard ratio.
↵a Calculated from the log-rank test.

Survival/Parameters	Unmethylated MGMT (n = 51)			Methylated MGMT (n = 37)
Survival/Parameters	Cutoff Value	HR (95% CI)	P Value^{^a}	Cutoff Value	HR (95% CI)	P Value^{^a}
OS
IAUC30_mean	≥10.9	3.04 (1.28–7.21)	.008	≥15.1	0.60 (0.17–2.14)	.429
IAUC60_mean	≥28.4	3.48 (1.20–10.14)	.015	≥32.0	0.42 (0.16–1.14)	.079
PFS
IAUC30_mean	≥10.9	2.60 (1.23–5.50)	.010	≥15.1	0.52 (0.18–1.56)	.238
IAUC60_mean	≥32.6	2.15 (1.14–4.05)	.015	≥32.8	0.24 (0.22–1.28)	.155