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Table 2: Reclassification improvement by adding IAUC parameters for predicting 1.5-year OS (n = 43) and 1-year PFS (n = 50) in the unmethylated MGMT group
Survival Time/Models AUC (95% CI) NRI (95% CI) P Value^{^a}
1.5-year OS (n = 43) 
    Model 0 (ref) Age, extent of resection, postoperative treatment, volume of enhancing tumors, eloquent brain involvement 0.81 (0.65–0.96) – –
    Model 1 IAUC30_mean 0.86 (0.74–0.98) 0.95 (0.61–1.29) .005
    Model 2 IAUC60_mean 0.86 (0.72–0.99) 0.81 (0.47–1.15) .018
1-year PFS (n = 50) 
    Model 0 (ref) Age, extent of resection, postoperative treatment, volume of enhancing tumors 0.69 (0.54–0.84) – –
    Model 1 IAUC30_mean 0.76 (0.62–0.90) 0.69 (0.39–0.98) .020
    Model 2 IAUC60_mean 0.74 (0.58–0.89) 0.56 (0.26–0.85) .059
Note:—NRI indicates net reclassification improvement; ref, reference.
↵a Calculated from category-less NRI.