Table 2:

Comparative overview of MR imaging biomarkers for adult and pediatric cohorts regarding genetic entity discrimination

Adult Cohort Imaging Criteria (n = 28)	P Value	Correspondence	P Value	Pediatric Cohort Imaging Criteria (n = 47)^{^a}
Hemorrhage^{^b}	.04^{^b}	No^{^b}	NS	Blood products
Edema volume^{^b}	.02^{^b}	No^{^b}	NS	Edema present
Hydrocephalus^{^b}	.03^{^b}	NA	NA	NA
Chang M-stage ≥2^{^b} (Chang on CET1WI plus spinal tap)	.02^{^b}	NA	NA	NA
Contact with lower rhombic lip^{^b}	.03^{^b}	NA	NA	NA
Chang T-stage >T2 on T2WI^{^b}	.01^{^b}	NA	NA	NA
Contact with fourth ventricle^{^b}	.02^{^b}	Pseudocorrespondence	<.005^{^b}	Midline/fourth ventricle^{^b}
Infiltration of vermis	.80	No^{^b}
Cysts	.82	Both NS	NS	Cyst
Contrast-enhancement homogeneity	.29	Both NS	NS	Enhancement pattern solid
Infiltration of cerebellar hemispheres	.08	No^{^b}	<.005^{^b}	Cerebellar hemisphere^{^b}
Contact with cerebellopontine angle	1.0	No^{^b}	<.005^{^b}	Contact with cerebellopontine angle^{^b}
Enhancement pattern	.81	No^{^b}	<.005^{^b}	Enhancement minimal to none^{^b}
Sharp margins	.63	No^{^b}	.03^{^b}	Ill-defined margins^{^b}
NA	NA	NA	NS	Enhancement pattern, other

Note:—NA indicates not available (parameter not analyzed); NS, criterion not significantly unbalancedly distributed, hence not identified a biomarker by Perreault et al.¹⁴
↵a Pediatric cohort: discovery cohort of Perreault el al.¹⁴ No identical MR imaging biomarkers could be identified among imaging criteria of both cohorts.
↵b MR imaging biomarkers that were identified by significantly imbalanced distribution between genetic entities.