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Table 3: ROC curve analyses of CBF_max and rCBF_max in discriminating high- and low-grade gliomas
Parameters/Patients AUC Youden Index Cutoff Value Sensitivity (%) Specificity (%) PPV (%) NPV (%) Accuracy (%)
CBF_max 
    All 0.828 0.690 91 mL/100 g/min 84.4 84.6 95.0 61.1 84.5
    Excluded^{^a} 0.859 0.829 91 mL/100 g/min 82.9 100 100 56.3 86.0
rCBF_max 
    All 0.863 0.668 1.19 82.2 84.6 94.9 57.9 82.8
    Excluded^{^a} 0.916 0.805 1.22 80.5 100 100 52.9 84.0
Note:—AUC indicates area under the curve; PPV, positive predictive value; NPV, negative predictive value.
↵a With oligodendrogliomas and anaplastic oligodendrogliomas excluded.

Parameters/Patients	AUC	Youden Index	Cutoff Value	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	Accuracy (%)
CBF_max
All	0.828	0.690	91 mL/100 g/min	84.4	84.6	95.0	61.1	84.5
Excluded^{^a}	0.859	0.829	91 mL/100 g/min	82.9	100	100	56.3	86.0
rCBF_max
All	0.863	0.668	1.19	82.2	84.6	94.9	57.9	82.8
Excluded^{^a}	0.916	0.805	1.22	80.5	100	100	52.9	84.0