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Table 3: Spearman correlations of tortuosity ratio with variables of interest to SVD and AD in LIFE MRI (n = 53)
ρ P Value
Age −0.023 .87
Race 0.202 .15
Sex −0.304 .03^{^a}
APOE4 0.454 .001^{^a}
Pulse pressure^{^b} 0.206 .14
VEGF −0.236 .096^{^a}
BDNF 0.227 .11
Hemoglobin level 0.266 .07^{^a}
Physical activity—daily oderate activity (min) −0.187 .20
3MS 0.199 .15
↵a Significant.
↵b Partial correlation of pulse pressure and tortuosity ratio adjusted for antihypertensive drug use.

	ρ	P Value
Age	−0.023	.87
Race	0.202	.15
Sex	−0.304	.03^{^a}
APOE4	0.454	.001^{^a}
Pulse pressure^{^b}	0.206	.14
VEGF	−0.236	.096^{^a}
BDNF	0.227	.11
Hemoglobin level	0.266	.07^{^a}
Physical activity—daily oderate activity (min)	−0.187	.20
3MS	0.199	.15