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Table 1: Study sample characteristics in the LIFE study at the Pittsburgh site
MRI Study (n = 53) Non-MRI Study (n = 163) P Value
Age (median) (IQR) (yr) 76.0 (5.8) 79.4 (9.0) <.01^{^a}
Race, non-Hispanic white (No.) (%) 30 (56.6) 124 (76.1) <.01^{^a}
Sex, female (No.) (%) 42 (79.2) 123 (75.5) .57
APOE4 allele presence^{^b} (No.) (%) 15 (31.9) 27 (20.0) .10
VEGF (median) (IQR) (pg/mL) 414.61 (370.17) – 
BDNF (median) (IQR) (pg/mL) 19,780.30 (27,492.00) – 
Pulse pressure (median) (IQR) 53 (13) 57 (18) .06
Physical activity—daily moderate activity (median) (IQR) (min) 24.6 (31.6) 18.3 (22.7) .05
3MS (median) (IQR) 93 (7) 92 (9) .46
Severe WMH burden^{^c} (No.) (%) 11 (20.8) – 
No microbleeds^{^d} (No.) (%) 21 (39.6) – 
Confounders 
    On antihypertensive medication (No.) (%) 39 (73.6) 119 (73.0) .93
    Hemoglobin level^{^e} (median) (IQR) (g/dL) 12.7 (1.2) 13.2 (2.0) .22
↵a Significant.
↵b Available on n = 47 (MRI) and n = 135 (non-MRI).
↵c WMH: rated as 0 = none/mild, 1 = moderate, 2 = severe.
↵d Available on n = 45 due to scan quality or motion; the remaining 24 were split nearly evenly between 1 and >1.
↵e Available on n = 47 (MRI) and n = 139 (non-MRI).