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Table 1: Patient^{^a} and tumor characteristics
Characteristics HPV− HNSCC (n = 84) HPV+ HNSCC (n = 21) P Value^{^b}
Average age (range), yr 65 (45–87) 61 (45–73) .15^{^c}
Sex, no. (%) 
    Women 23 (27) 7 (33) 
    Men 61 (73) 14 (67) .79^{^d}
Tumor location, no. (%) 
    Oral cavity 50 (60) 3 (14) 
    Oropharynx 34 (40) 18 (86) <.001^{^d}
T classification according to AJCC 2017, no. (%)^{^f} 
    T1 5 (6) 1 (5) 
    T2 22 (26) 6 (29) 
    T3 15 (18) 3 (14) 
    T4 42 (50) 11 (52) 1^{^e}
N classification according to AJCC 2017, no. (%) 
    N0 36 (43) 4 (19) 
    N1 13 (15) 6 (29) 
    N2 35 (42) 9 (43) 
    N3 0 (0) 2 (9) .012^{^e}
M classification according to AJCC 2017, no. (%) 
    M0 77 (92) 18 (86) 
    M1 1 (1) 1 (5) 
    Mx 6 (7) 2 (9) .47^{^e}
Tumor keratinization, no. (%) 
    Present 65 (77) 8 (38) 
    Absent 19 (23) 13 (62) .001^{^d}
Degree of keratinization, no. (%) 
    Keratinizing 48 (57) 3 (14) 
    Focally keratinizing 17 (20) 5 (24) <.001^{^e}
    Nonkeratinizing, no. (%) 19 (23) 13 (62) 
Histologic differentiation, no. (%) 
    Well differentiated 15 (18) Not assessable^{^f} 
    Moderately differentiated 48 (57) 
    Poorly differentiated 21 (25) 
Semiquantitative histologic score, no. (%)^{^g} 
    Score 1 (most heterogeneous) 14 (17) 0 (0) 
    Score 2 8 (9) 0 (0) 
    Score 3 41 (49) 7 (33) .002^{^e}
    Score 4 12 (14) 5 (24) 
    Score 5 (most homogeneous) 9 (11) 9 (43) 
Mean proliferation index, MIB-1 (%)^{^h} 49 71 .005^{^c}
    Range in % 8–90 30–95 
Note:—AJCC indicates American Joint Committee on Cancer.
↵a Total patients, 105.
↵b P values are indicated for the comparisons between HPV+ and HPV− HNSCCs.
↵c Wilcoxon rank sum test.
↵d Pearson χ² test.
↵e Fisher test.
↵f HPV+ HNSCC was not graded according to AJCC 2017 guidelines.³
↵g The semiquantitative histologic score is described in On-line Table 1.
↵h Available in 95 histologic samples.