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Table 3: Observed mean values and slopes of R₁, R₂, and PD of the entire brain and gray and white matter as a function of subject age
Brain Gray Matter White Matter
R₁ intercept (s⁻¹) 1.151 0.897 1.495
R₁ slope (s⁻¹/y) 0.00054 0.00015 −0.00063
R₁ slope (95% CI) (s⁻¹/y) (0.0002–0.0010) (−0.0001–0.0002) (−0.0011–0.0002)
R₁ slope P value .04 .4 .2
R₂ intercept (s⁻¹) 11.44 10.57 12.62
R₂ slope (s⁻¹/y) −0.0001 −0.0018 −0.0056
R₂ slope (95% CI) (s⁻¹/y) (−0.004–0.002) (−0.004–0.001) (−0.009–0.000)
R₂ slope P value .5 .3 .05
PD intercept (%) 75.65 82.44 67.44
PD slope (%/y) −0.026 −0.019 0.009
PD slope (95% CI) (%/y) (−0.039–0.013) (−0.025 to −0.013) (−0.003–0.020)
PD slope P value <.001 <.001 .2
Note:—y indicates year.

	Brain	Gray Matter	White Matter
R₁ intercept (s⁻¹)	1.151	0.897	1.495
R₁ slope (s⁻¹/y)	0.00054	0.00015	−0.00063
R₁ slope (95% CI) (s⁻¹/y)	(0.0002–0.0010)	(−0.0001–0.0002)	(−0.0011–0.0002)
R₁ slope P value	.04	.4	.2
R₂ intercept (s⁻¹)	11.44	10.57	12.62
R₂ slope (s⁻¹/y)	−0.0001	−0.0018	−0.0056
R₂ slope (95% CI) (s⁻¹/y)	(−0.004–0.002)	(−0.004–0.001)	(−0.009–0.000)
R₂ slope P value	.5	.3	.05
PD intercept (%)	75.65	82.44	67.44
PD slope (%/y)	−0.026	−0.019	0.009
PD slope (95% CI) (%/y)	(−0.039–0.013)	(−0.025 to −0.013)	(−0.003–0.020)
PD slope P value	<.001	<.001	.2