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Table 3: DTI derivate metrics in patients with MNGIE and healthy controls
ROI MD (Mean ± SD) FA (Mean ± SD) AD (Mean ± SD) RD (Mean ± SD)
PO-WM 
    MNGIE 1.09 ± 0.16 0.27 ± 0.05 1.40 ± 0.16 0.93 ± 0.16
    Controls 0.79 ± 0.05 0.40 ± 0.02 1.14 ± 0.07 0.61 ± 0.05
    P Value^{^a} <.0001^{^b} <.0001^{^b} .0001^{^b} <.0001^{^b}
OR 
    MNGIE 1.15 ± 0.20 0.41 ± 0.07 1.69 ± 0.19 0.88 ± 0.21
    Controls 0.81 ± 0.05 0.59 ± 0.09 1.35 ± 0.12 0.54 ± 0.06
    P Value^{^a} <.0001^{^b} .0003^{^b} .0002^{^b} <.0001^{^b}
PLIC 
    MNGIE 0.78 ± 0.06 0.61 ± 0.07 1.40 ± 0.06 0.47 ± 0.08
    Controls 0.69 ± 0.05 0.70 ± 0.04 1.36 ± 0.11 0.35 ± 0.05
    P Value^{^a} .0019^{^b} .0008^{^b} 0.36 .0003^{^b}
CC 
    MNGIE 0.88 ± 0.08 0.66 ± 0.06 1.64 ± 0.11 0.49 ± 0.10
    Controls 0.81 ± 0.09 0.76 ± 0.06 1.72 ± 0.19 .35 ± 0.08
    P Value^{^a} .12 .0012^{^b} 0.37 .0028^{^b}
Note:—OR indicates optic radiation; CC, corpus callosum.
↵a Statistical significance was set at P < .003 after Bonferroni correction for multiple comparisons.
↵b Significant.