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Table 2: ¹H-MRS white matter parieto-occipital metabolite absolute concentrations, ratios, and water signal intensity, and T2 values in patients with MNGIE and healthy controls
Patients with MNGIE (n = 7) (mean ± SD) Healthy Controls (n = 9) (mean ± SD) P Value^{^a}
Metabolite concentrations (mM) 
    NAA 6.98 ± 0.79 9.81 ± 0.94 <.001^{^a,^c}
    Cr 4.15 ± 0.48 5.97 ± 0.55 <.001^{^a,^c}
    Cho 1.53 ± 0.23 1.89 ± 0.24 .01^{^a}
    mIns 4.46 ± 1.14 5.44 ± 0.76 .06^{^a}
Metabolite ratios 
    NAA/Cr 1.85 ± 0.18 1.80 ± 0.11 .57^{^b}
    Cho/Cr 0.39 ± 0.06 0.33 ± 0.04 .04^{^b}
    mIns/Cr 0.99 ± 0.27 0.85 ± 0.08 .16^{^b}
Water signal (a.u.) 
    S_BW (0) (14.0 ± 9.0)×10¹⁰ (10.8 ± 2.0)×10¹⁰ .370
    S_CSF (0) (4.0 ± 7.5)×10¹⁰ (1.3 ± 0.6)×10¹⁰ .23^{^a}
T2 water 
    T_2BW (ms) 112 ± 24 75 ± 8 .001^{^a,^c}
    T_2CSF (ms) 520 ± 185 776 ± 344 .098^{^a}
Note:—a.u. indicates arbitrary units; S_BW (0) and S_CSF (0), water signals corresponding to brain and cerebrospinal water, respectively; T_2BW and T_2CSF, water relaxation times corresponding to brain and cerebrospinal water, respectively.
↵a Statistical significance was set at P < .0125 after Bonferroni correction for multiple comparisons.
↵b Statistical significance was set at P < .0167 after Bonferroni correction for multiple comparisons.
↵c Significant.