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Demographics and diffusion and volumetric analysis by region
Control (n = 100) TTH (n = 31) MTH (n = 23)
Demographics 
    Median age (range) (mo) 98 (4–213) 99 (24–209) 83 (12–212)
    Sex (M/F) 36:64 13:18 6:17
    Family history of any headache (No.) (%) 6 (19%) 10 (43%)
ADC on neuroimaging ([mean ×10⁻⁶ mm²/s], standard error,^{^a} P value vs control) 
    Cerebral cortex 899.05 (3.44) 901.78 (7.04) >.5 907.29 (8.22) >.5
    Thalamus 812.48 (3.51) 815.44 (6.26) >.5 833.11 (7.11) .045^{^b}
    Caudate 815.16 (3.98) 821.42 (7.11) >.5 833.99 (8.64) .149
    Putamen 799.94 (3.48) 792.42 (6.21) >.5 800.75 (7.55) >.5
    Pallidum 836.62 (4.05) 822.09 (7.22) .24 838.30 (8.78) >.5
    Hippocampus 935.52 (4.50) 965.45 (8.03) .013^{^b} 970.46 (9.76) .038^{^b}
    Amygdala 885.83 (3.79) 882.75 (6.78) >.5 904.48 (8.24) .113
    Nucleus accumbens 856.83 (4.72) 841.45 (8.43) .34 850.75 (8.43) >.5
    Brain stem 806.72 (3.43) 825.01 (6.13) .05^{^b} 840.71 (7.45) <.001^{^b}
Volume on neuroimaging (mean [in mL], standard error,^{^a} P value vs control) 
    Cerebral cortex 344.33 (4.19) 350.56 (3.92) >.5 362.54 (9.08) .212
    Thalamus 6.62 (0.08) 5.54 (0.12) .148 5.71 (0.15) >.5
    Caudate 2.68 (0.04) 2.64 (0.06) >.5 2.71 (0.08) >.5
    Putamen 4.49 (0.06) 4.46 (0.06) >.5 4.63 (0.12) >.5
    Pallidum 1.46 (0.02) 1.42 (0.03) >.5 1.50 (0.04) >.5
    Hippocampus 3.10 (0.04) 3.07 (0.07) >.5 3.21 (0.08) >.5
    Amygdala 1.53 (0.02) 1.55 (0.04) >.5 1.59 (0.04) >.5
    Nucleus accumbens 0.37 (0.01) 0.38 (0.04) >.5 0.039 (0.01) >.5
    Brain stem 22.79 (0.30) 22.51 (0.53) .108 22.97 (0.64) >.5
↵a Means and standard error were corrected to an age of 97 months in all groups.
↵b Significant.