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Table 3: Imaging features of initial metastases with respect to their molecular group assignment^{^a}
MRI Signals Initial Metastasis (n = 25)
WNT (n = 0) (%) SHH (n = 3) (%) Group 3 (n = 8) (%) Group 4 (n = 14) (%) P Value^{^b}
Ependymal C−/D+ 0 (0) 0 (0) (0) 6 (42.8) .01^{^c}
3rd V.I.R, C−/D+^{^d} 0 (0) (0) (0) 4 (28.6) .02^{^c}
Ependymal C+/D+ 0 (0) 0 (0) 3 (37.5) 0 (0) .02^{^c}
Leptomeningeal C−/D+ 0 (0) 0 (0) 0 (0) 3 (21.4) .05
Leptomeningeal C+/D+ 0 (0) 3 (100) 5 (62.5) 5 (35.7) .17
Leptomeningeal C+/D− 0 (0) 0 (0) 0 (0) 4 (28.6) .02^{^c}
Note:—C− indicates no contrast enhancing; D+, diffusion-restricting; D−, no diffusion-restricting; C+, contrast-enhancing; 3rd V.I.R, third ventricle infundibular recess.
↵a The sum of metastases in some locations is higher than the total number of patients in the group because each case could have multiple metastases in >1 compartment.
↵b P value determined using the Fisher exact test.
↵c Statistically significant.
↵d Subgroup of patients with mismatching ependymal metastasis in the third ventricle infundibular recess.