Table 2:

Correlations between lesion and volumetric MRI measures of WM and GM with clinical and neuropsychological variables (age-adjusted linear mixed-effect model with random intercept for recruitment site, false discovery rate–corrected)^{^a}

MRI Measure	Global Cognitive Z Score	Attention Z Score	Visual Memory Z Score	Executive Functions (WCSTpr)	EDSS
T2 LV	−0.35 (.01)	−0.33 (.008)	−0.34 (.03)	−0.25 (.06)	NS
T1 LV	−0.31 (.02)	−0.31 (.01)	−0.33 (.03)	−0.28 (.05)	NS
NBV	0.44 (.01)	0.44 (.001)	0.35 (.03)	NS	−0.33 (.01)
NGMV	0.36 (.01)	0.31 (.01)	NS	NS	NS
NCGMV	0.42 (.01)	0.36 (.01)	NS	NS	NS
NWMV	0.37 (.01)	0.40 (.004)	0.35 (.03)	NS	−0.35 (.008)
Total normalized deep GM volume	0.40 (.001)	0.47 (<.001)	0.33 (.04)	NS	−0.29 (.03)
Average normalized thalamus volume	0.36 (.002)	0.41 (.0005)	0.30 (.05)	NS	NS
Average normalized caudate volume	0.40 (.001)	0.50 (<.001)	NS	NS	NS
Average normalized putamen volume	0.40 (.001)	0.46 (.0001)	0.37 (.03)	NS	−0.30 (.03)
Average normalized pallidum volume	0.25 (.03)	0.34 (.003)	NS	NS	−0.35 (.01)
Average normalized hippocampus volume	0.39 (.001)	0.34 (.003)	NS	NS	NS
Average normalized amygdala volume	0.33 (.01)	0.33 (.01)	NS	NS	NS
Average normalized accumbens volume	0.32 (.009)	0.36 (.003)	NS	NS	NS

Note:—NS indicates not significant; WCSTpr, Wisconsin Card Sorting Test, number of perseverative responses; NBV, normalized brain volume; NGMV, normalized GM volume; NCGMV, normalized cortical GM volume; NWMV, normalized WM volume.
↵a Correlations are reported as standardized coefficients (to include size effect), and P values are reported in parentheses.