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Table 2: Results of subgroup analysis
Parameters End Point Factor No. of Studies HR 95% CI of HR P Value I² (%) Model
TNR OS Tumor grade (high) 7 1.76 1.36–2.28 <.001^{^a} 22 Fixed
Tumor grade (low) 6 2.19 0.98–4.86 .05^{^b} 97 Random
TNR OS Tumor stage (primary) 9 1.95 1.45–2.63 <.001^{^a} 55 Random
Tumor stage (recurrence) 2 2.58 1.31–5.08 .006^{^a} 0 Fixed
TNR OS Calculation method of TNR (tumor SUVmax/normal contralateral SUVmean) 8 1.97 1.42–2.74 <.001^{^a} 60 Random
Calculation method of TNR (others) 3 2.15 1.29–3.60 .003^{^a} 0 Fixed
MTV OS Tumor grade (high) 2 5.54 3.11–9.86 <.001^{^a} 0 Fixed
MTV OS Tumor stage (primary) 2 3.51 1.04–11.88 .04^{^a} 85 Random
MTV OS Reference for MTV (1.3 × SUVmean of normal contralateral cortex) 2 3.51 1.04–11.88 .04^{^a} 85 Random
↵a Statistically significant (P < .05).
↵b Significant trend (.05 ≤ P ≤ .10).

Parameters	End Point	Factor	No. of Studies	HR	95% CI of HR	P Value	I² (%)	Model
TNR	OS	Tumor grade (high)	7	1.76	1.36–2.28	<.001^{^a}	22	Fixed
TNR	OS	Tumor grade (low)	6	2.19	0.98–4.86	.05^{^b}	97	Random
TNR	OS	Tumor stage (primary)	9	1.95	1.45–2.63	<.001^{^a}	55	Random
TNR	OS	Tumor stage (recurrence)	2	2.58	1.31–5.08	.006^{^a}	0	Fixed
TNR	OS	Calculation method of TNR (tumor SUVmax/normal contralateral SUVmean)	8	1.97	1.42–2.74	<.001^{^a}	60	Random
TNR	OS	Calculation method of TNR (others)	3	2.15	1.29–3.60	.003^{^a}	0	Fixed
MTV	OS	Tumor grade (high)	2	5.54	3.11–9.86	<.001^{^a}	0	Fixed
MTV	OS	Tumor stage (primary)	2	3.51	1.04–11.88	.04^{^a}	85	Random
MTV	OS	Reference for MTV (1.3 × SUVmean of normal contralateral cortex)	2	3.51	1.04–11.88	.04^{^a}	85	Random