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Table 2: Diagnostic performance of weighted and unweighted biomarkers^{^a}
Threshold Sensitivity Specificity
Unweighted biomarker (ψ_i) 0.38 1.00 (0.75–1.00) 0.67 (0.42–0.84)
0.40 0.94 (0.70–1.00) 0.67 (0.42–0.84)
0.44 0.75 (0.50–0.90) 0.73 (0.47–0.89)
0.50 0.56 (0.25–0.65) 0.80 (0.58–0.94)
Weighted biomarker (ψ_i^w) 0.37 0.94 (0.70–1.00) 0.73 (0.42–0.84)
0.40 0.75 (0.50–0.90) 0.73 (0.42–0.84)
0.46 0.63 (0.40–0.80) 0.93 (0.68–1.00)
0.50 0.56 (0.35–0.75) 0.93 (0.74–1.00)
↵a Data in column 2 represent the given cutoff values; data in parentheses are the relevant 95% confidence intervals.

	Threshold	Sensitivity	Specificity
Unweighted biomarker (ψ_i)	0.38	1.00 (0.75–1.00)	0.67 (0.42–0.84)
	0.40	0.94 (0.70–1.00)	0.67 (0.42–0.84)
	0.44	0.75 (0.50–0.90)	0.73 (0.47–0.89)
	0.50	0.56 (0.25–0.65)	0.80 (0.58–0.94)
Weighted biomarker (ψ_i^w)	0.37	0.94 (0.70–1.00)	0.73 (0.42–0.84)
	0.40	0.75 (0.50–0.90)	0.73 (0.42–0.84)
	0.46	0.63 (0.40–0.80)	0.93 (0.68–1.00)
	0.50	0.56 (0.35–0.75)	0.93 (0.74–1.00)