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Table 1: Clinical and US features and characteristics of thyroid nodules with benign cytology
Positive for BRAF V600E Mutation Negative for BRAF V600E Mutation P
No. of nodules 36 256 
Diagnosis <.001
    Malignant 31 6 
    Benign 5 250 
Age (mean) (yr) 44.7 ± 11.3 47.3 ± 13.9 .31
Sex <.001
    F 2 229 
    M 10 27 
Mean size of nodules (mm) 9.4 ± 3.7 11.8 ± 4.1 .41
    5–10 23 145 
    >10 13 112 
No. of suspicious US features <.001
    1 11 243 
    2 17 12 
    3 7 1 
    4 1 0 
Echogenicity .11
    Hyper- or isoechoic 1 15 
    Hypoechoic 30 229 
    Marked hypoechoic 5 12 
Margin .18
    Circumscribed 15 137 
    Not circumscribed 21 119 
Calcification <.001
    No calcifications 12 161 
    Microcalcification 21 72 
    Macrocalcification 3 23 
Shape <.01
    Parallel 16 167 
    Taller-than-wide 20 89 
Evidence of extrathyroidal growth 0 0 
Pathologic adenopathy 2 0

	Positive for BRAF V600E Mutation	Negative for BRAF V600E Mutation	P
No. of nodules	36	256
Diagnosis			<.001
Malignant	31	6
Benign	5	250
Age (mean) (yr)	44.7 ± 11.3	47.3 ± 13.9	.31
Sex			<.001
F	2	229
M	10	27
Mean size of nodules (mm)	9.4 ± 3.7	11.8 ± 4.1	.41
5–10	23	145
>10	13	112
No. of suspicious US features			<.001
1	11	243
2	17	12
3	7	1
4	1	0
Echogenicity			.11
Hyper- or isoechoic	1	15
Hypoechoic	30	229
Marked hypoechoic	5	12
Margin			.18
Circumscribed	15	137
Not circumscribed	21	119
Calcification			<.001
No calcifications	12	161
Microcalcification	21	72
Macrocalcification	3	23
Shape			<.01
Parallel	16	167
Taller-than-wide	20	89
Evidence of extrathyroidal growth	0	0
Pathologic adenopathy	2	0