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Table 2: 
Characteristic brain MR imaging findings in WSS
PatientSex/Age (yr)White MatterDescriptive Features on MRIComments
Iron DepositionPituitary AtrophyDiffusion Restriction
FrontalParietalTemporalOccipitalInfratentorialCaudatePutamenRN/SN
1F/18++−+−−−−++−
2M/19−−−−−−+−+−Initial study showed no iron deposition
3F/29++++++−−−+++−−Extension of iron deposition on follow-up study
4F/38++++++−++−++Prominent perivascular spaces
5F/35+++−−−+−−−Prominent perivascular spaces
6F/37++++++++−−+−+−Calcification of the dentate nucleus
7M/45++++++++−++−++Loss of corpus callosum volume
8M/22++−−−−+−+−−
9M/24++−−−−+−−−Prominent perivascular spaces
10M/23++−−−−−−+−−
11F/21++−−−−+−+−−
12M/16++−−−−−−+−Prominent perivascular spaces
13M/26++++−−+++−−
14M/21−−−−−−++−−−
15M/20+−−−−−−−+−−
16F/21−−−−−−+++−−
17F/32++++−−+−+−−
18F/22−−−−−−−−+−−
19F/35+++++++++−+−+−Pontine WM signal
20M/21−−−−−−+++−−
21F/27−−−−−−+−+−−
22M/16−−−−−−−−+−−
23F/41++++++−++++−−
24M/37++++++−++−+−Dentate nucleus calcification
25F/17−−−−−−+−−−−
26F/29+++++−−−−−Cerebellar WM signal
  • Note:—RN indicates red nucleus; SN, substantia nigra; −, absent; +, mild (predominantly scattered lesions or confluent periventricular); ++, moderate (patchy scattered); +++, severe (predominantly diffuse, vanishing lesions).