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Table 4: Results of the analyses exploring the relationship between MRI measures and DGM volume in the MS subgroups
DGM Volumes Model Predictor
R² (ΔR²) F (ΔF) P Value Standardized β T P Value
RRMS 
    Thalamus 0.750 (0.081) 6.637 (5.738) <.001 
        DMT −0.289 −2.313 .03
        LL −0.454 −3.214 .003
        MD thalamus −0.371 −2.395 .02
    Caudate 0.563 (0.061) 6.662 (4.346) <.001 
        DMT −0.352 −2.702 .01
        LL −0.411 −2.938 .006
        MD caudate −0.287 −2.085 .04
    Putamen 0.662 (0.196) 7.187 (16.073) <.001 
        DMT −0.497 −4.166 <.001
        LL −0.502 −4.009 <.001
    Globus pallidus 0.611 (0.158) 5.484 (11.608) <.001 
        DMT −0.487 −3.868 <.001
        LL −0.450 −3.407 .001
PMS 
    Thalamus 0.832 (0.585) 7.761 (19.119) <.001 
        MD thalamus −0.566 −3.091 .01
        χ thalamus 0.493 2.233 .05
    Caudate 0.799 (0.576) 7.362 (18.587) .001 
        FA caudate −0.783 −5.789 <.001
    Putamen 0.580 (0.506) 3.228 (16.890) .03^{^a} 
        FA putamen −0.836 −4.110 .001
↵a Not significant after Bonferroni correction.

DGM Volumes	Model			Predictor
DGM Volumes	R² (ΔR²)	F (ΔF)	P Value	Standardized β	T	P Value
RRMS
Thalamus	0.750 (0.081)	6.637 (5.738)	<.001
DMT				−0.289	−2.313	.03
LL				−0.454	−3.214	.003
MD thalamus				−0.371	−2.395	.02
Caudate	0.563 (0.061)	6.662 (4.346)	<.001
DMT				−0.352	−2.702	.01
LL				−0.411	−2.938	.006
MD caudate				−0.287	−2.085	.04
Putamen	0.662 (0.196)	7.187 (16.073)	<.001
DMT				−0.497	−4.166	<.001
LL				−0.502	−4.009	<.001
Globus pallidus	0.611 (0.158)	5.484 (11.608)	<.001
DMT				−0.487	−3.868	<.001
LL				−0.450	−3.407	.001
PMS
Thalamus	0.832 (0.585)	7.761 (19.119)	<.001
MD thalamus				−0.566	−3.091	.01
χ thalamus				0.493	2.233	.05
Caudate	0.799 (0.576)	7.362 (18.587)	.001
FA caudate				−0.783	−5.789	<.001
Putamen	0.580 (0.506)	3.228 (16.890)	.03^{^a}
FA putamen				−0.836	−4.110	.001