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Table 2: 
MRI metrics for all subjects included in the analysisa
MSHCP Value (MS vs HC)PMSRRMSP Value (PMS vs RRMS)
LL13.8 ± 16.2NANA18.3 ± 16.711.6 ± 15.7.03c
NBV1467.8 ± 86.91547.2 ± 67.7<.001b1440.0 ± 101.71481.2 ± 76.3.17
NGMV745.8 ± 60.4793.5 ± 54.8<.001b724.7 ± 66.3755.9 ± 55.3.09
NWMV722.0 ± 36.6753.6 ± 27.6<.001b715.3 ± 46.4725.3 ± 30.7.31
DGM Volumes
    Thalamus18.7 ± 2.621.9 ± 2.1<.001b17.4 ± 3.119.4 ± 2.1.005b
    Caudate8.4 ± 1.49.5 ± 1.2<.001b7.7 ± 1.68.7 ± 1.1.007b
    Putamen12.3 ± 1.813.8 ± 1.8<.001b11.5 ± 1.312.9 ± 1.5.02c
    Globus pallidus4.5 ± 0.75.0 ± 0.6<.001b4.1 ± 0.84.6 ± 0.5.001b
DGM Diffusion
    MD thalamus0.95 ± 0.090.88 ± 0.06<.001b0.98 ± 0.110.96 ± 0.11.25
    MD caudate1.00 ± 0.100.92 ± 0.08<.001b1.04 ± 0.100.98 ± 0.10.05c
    FA putamen0.272 ± 0.0240.263 ± 0.019.02c0.282 ± 0.0290.267 ± 0.020.05c
DGM Perfusion
    rCBV caudate2.8 ± 1.03.1 ± 1.0.122.3 ± 1.03.0 ± 0.9.002b
DGM Susceptibility
    χ thalamus−26.8 ± 31.4−7.7 ± 22.4.001b−38.7 ± 31.4−21.1 ± 30.1.14
  • Note:—NBV indicates normalized brain volume; NGMV, normalized gray matter volume; NWMV, normalized white matter volume; NA, not applicable.
  • ↵a Values are expressed as means ± SD (volume in milliliters, MD in ×10−3 mm2/s, rCBV in milliliters/100 mL, FA is a scalar value between 0 and 1, χ is in parts per billion).
  • ↵b Significant difference.
  • ↵c Not significant after Bonferroni correction.