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Table 2: Mixed-density and hypodense SDCs—2 typical problem constellations during the initial CT investigation^{^a}
CT Finding Differential Diagnosis Pathophysiology Forensic Relevance
Heterogeneous hypo- and hyperdense SDC (mixed-density pattern) 
1) Hyperacute + acute SDH Unclotted and clotted blood Compatible with 1 hemorrhagic event
Assumed EoA: 0–24 hr
2) Acute SDH Compacted clot with serum separation Compatible with 1 hemorrhagic event
Assumed EoA: 1–3 days
3) SDHHy “Acute blood” and CSF, eg, due to BV injury and concomitant arachnoid tear Compatible with 1 hemorrhagic event
Assumed EoA: 1 day–min 1 wk
4) Acute + chronic SDH Acute hemorrhage within a pre-existing cSDH/SDHy Compatible with 2 (or more) hemorrhagic events
Assumed EoA: 0–min. 2 wk
Homogeneous iso- to hypodense SDC 
1) Hyperacute SDH Unclotted blood Assumed EoA: 0–24 hr
2) Acute SDH + anemia Clotted blood with decreased number of erythrocytes Assumed EoA: 1–3 days
3) SDHy/SDHHy CSF or CSF + acute blood Assumed EoA: 1 day–min. 1 wk
4) Late subacute SDH Lysis of erythrocytes Assumed EoA: 1–3 wk
5) cSDH Serosanguinous fluid Assumed EoA: min. 2 wk
Note:—EoA indicates estimate of age; min, minimum.
↵a According to Hymel et al,20 Hedlund,22 Vezina,28 and Tung et al.30